Safety First

Safety & Contraindications

GLP-1 medications such as tirzepatide and semaglutide are widely used and well-studied. For most patients, they are safe and effective when prescribed and monitored appropriately. This page explains who should not use GLP-1 therapy, situations that require closer monitoring, and when to contact FMC.

Not for everyone

Who should not use GLP-1 medications:

GLP-1 therapy may not be appropriate if you have certain medical histories. If any of the following apply to you, tell your FMC clinician before starting or continuing treatment.

  • Medullary Thyroid Carcinoma (MTC) — personal or family history.
  • MEN 2 (Multiple Endocrine Neoplasia type 2).
  • Severe motility disorders such as severe gastroparesis or a history of bowel obstruction related to motility problems.
  • Known allergy to tirzepatide, semaglutide, or similar medications.

Conditions that may require extra monitoring:

Many patients with the conditions below can still use GLP-1 therapy safely. The key is individualized pacing, hydration support, and proactive follow-up.

Gallbladder history

  • Prior gallstones or gallbladder inflammation.
  • Rapid weight loss can increase gallstone risk.

Pancreatitis history

  • Used cautiously with close monitoring.
  • Report severe or persistent abdominal pain promptly.

Kidney disease

  • Dehydration from nausea/vomiting can affect kidney function.
  • Hydration and dose pacing matter.

Diabetes meds that can cause lows

  • Insulin and sulfonylureas can increase hypoglycemia risk.
  • Dose adjustments may be needed.

Pregnancy & breastfeeding

  • GLP-1 medications are generally not recommended.
  • Notify FMC promptly if pregnancy occurs.

Recent dose changes

  • Side effects often appear after dose increases.
  • Earlier outreach allows safer adjustments.
Reach out promptly

When to contact FMC:

Contact your FMC care team if you experience symptoms that feel severe, unusual, or persistent. Early communication helps us adjust treatment safely.

  • Persistent vomiting or inability to keep fluids down.
  • Severe abdominal pain, especially if it radiates to the back.
  • Yellowing of the skin or eyes, or right-sided upper abdominal pain (possible gallbladder concern).
  • Allergic reaction symptoms such as swelling, rash, or difficulty breathing.
  • Any symptom that feels different, worsening, or concerning.

Your safety comes first:

At FMC, every patient completes a medical intake review, and dosing is personalized. If you are ever unsure whether a symptom or medical history matters, reach out. It’s always better to ask early.

Note

This page is educational and does not replace individualized medical advice. Always follow your FMC clinician’s guidance and your prescribed plan.

Tip

If symptoms begin after a dose increase, don’t “push through” alone—small timing, hydration, or pacing changes often fix the issue quickly.

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